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KMID : 0360220090500111692
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Journal of the Korean Ophthalmological Society
2009 Volume.50 No. 11 p.1692 ~ p.1697
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Long-Term Study of Levodopa/Carbidopa for Refractory Childhood Amblyopia
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Kim Young-Ho
Koh Seung-Beom
Cho Yoon-A
Kim Seung-Hyun
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Abstract
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Purpose: To evaluate the long-term (12 to 30 months) effect of L-dopa with part-time occlusion in patients in which occlusion therapy failed.
Methods: Seventeen eyes of 12 amblyopic children who failed with part-time occlusion (4 to 8 hours/day) treatment for a minimum period of 6 months were studied. The follow-up period was 12 to 30 months. The average best corrected visual acuity (BCVA) before treatment was 0.28±0.20 (0.05-0.5). After full informed consent was obtained from their parents, the children received levodopa (2 to 4 mg/kg) for 8 weeks combined with part-time occlusion and spectacles.
Results: The average age of the subjects was 7.0±2.7 years and the mean follow-up period was 23.7±7.7 (12 to 30) months. After the administration of levodopa for 8 weeks, 9 eyes (53%) showed improvement in BCVA, and only 4 eyes showing a mean regression of 0.20±0.11 logMAR visual acuities. The BCVA reached the maximum value after a mean of 8.47 months. After 8 weeks from baseline, 13 eyes (76%) reached the maximum BCVA. After 12 to 30 months of follow-up, 12 out of 17 eyes (70.6%) showed a BCVA improvement of 0.14±0.19 logMAR.
Conclusions: After the long-term (12 to 30 months) follow-up, L-dopa with part-time occlusion in patients in which occlusion therapy failed showed improved visual acuities in 76% of the cases.
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KEYWORD
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Amblyopia, L-dopa
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